Publications and Preprints

Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones
Clonally expanded CD4+ T-cells harboring rebound-competent HIV persist lifelong during ART1-5. Latency is considered the principal …
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Predicting Imminent Conversion to Exudative Age-Related Macular Degeneration Using Multimodal Data and Ensemble Machine Learning
OBJECTIVE. Exudative age-related macular degeneration (eAMD) is a major cause of central vision loss. Identifying patients at high risk …
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The trouble with triples: Examining the impact of measurement error in mediation analysis
Mediation analysis is used in genetic mapping studies to identify candidate gene mediators of quantitative trait loci (QTL). We …
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A Bayesian model selection approach to mediation analysis
Mediation analysis is a powerful tool for discovery of causal relationships. We describe a Bayesian model selection approach to …
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Quantification of the Impact of Partition Coefficient Prediction Methods on Physiologically Based Pharmacokinetic Model Output Using a Standardized Tissue Composition
Tissue:plasma partition coefficients are key parameters in physiologically based pharmacokinetic (PBPK) models, yet the coefficients …
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Morphine Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure
OBJECTIVE: To develop a pharmacokinetic-pharmacogenomic population model of morphine in critically ill children with acute respiratory …
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Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure
OBJECTIVES: To develop a pharmacokinetic-pharmacogenomic population model of midazolam in critically ill children with primary …
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